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| | Ac-RLR-AMC (trifluoroacetate salt) Basic information |
| | Ac-RLR-AMC (trifluoroacetate salt) Chemical Properties |
| solubility | Acetic Acid (5%): soluble |
| | Ac-RLR-AMC (trifluoroacetate salt) Usage And Synthesis |
| Description | Ac-RLR-AMC is a fluorogenic substrate for the 26S proteasome.1,2 Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes. AMC displays excitation/emission maxima of 380/440-460 nm, respectively.WARNING This product is not for human or veterinary use. | | References | [1] ALEXEI F KISSELEV Alfred L G. Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates.[J]. Methods in enzymology, 2005, 398: 364-378. DOI: 10.1016/s0076-6879(05)98030-0
[2] DAVID VILCHEZ. RPN-6 determines C. elegans longevity under proteotoxic stress conditions[J]. Nature, 2012, 489 7415: 263-268. DOI: 10.1038/nature11315 |
| | Ac-RLR-AMC (trifluoroacetate salt) Preparation Products And Raw materials |
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