Ac-Leu-Glu-His-Asp-AMC manufacturers
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| | Ac-Leu-Glu-His-Asp-AMC Basic information |
| Product Name: | Ac-Leu-Glu-His-Asp-AMC | | Synonyms: | N-ACETYL-LEU-GLU-HIS-ASP-7-AMINO-4-METHYLCOUMARIN AMC;CASPASE-9 SUBSTRATE (FLUOROGENIC);ACETYL-L-LEUCYL-L-GLUTAMYL-L-HISTIDYL-L-ASPARTIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE);AC-LEHD-MCA;AC-LEHD-AMC;AC-LEHD-AMC TRIFLUOROACETATE SALT;AC-LEU-GLU-HIS-ASP-7-AMINO-4-METHYLCOUMARIN;AC-LEU-GLU-HIS-ASP-AMC TRIFLUOROACETATE SALT | | CAS: | 292633-16-0 | | MF: | C33H41N7O11 | | MW: | 711.72 | | EINECS: | | | Product Categories: | peptide;Pepetides | | Mol File: | 292633-16-0.mol |  |
| | Ac-Leu-Glu-His-Asp-AMC Chemical Properties |
| Boiling point | 1258.1±65.0 °C(Predicted) | | density | 1.388±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | Water: 1 mg/ml | | form | Lyophilized Powder | | pka | 4.07±0.10(Predicted) | | color | White to off-white | | Water Solubility | 1mg/mL in water |
| | Ac-Leu-Glu-His-Asp-AMC Usage And Synthesis |
| Description | Ac-LEHD-AMC is a fluorogenic substrate for caspase-9. Ac-LEHD-AMC is cleaved by caspase-9 to release the fluorescent moiety AMC, which can be used to quantify caspase-9 activity. | | Uses | Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity[1]. | | References | [1] Igor M Prudnikov, et al. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. J Biochem. 2012 Mar;151(3):299-316. DOI:10.1093/jb/mvs001 | | Sequene | Ac-Leu-Glu-His-Asp-AMC |
| | Ac-Leu-Glu-His-Asp-AMC Preparation Products And Raw materials |
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