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| | KH 176
(KH176) Basic information |
| | KH 176
(KH176) Chemical Properties |
| storage temp. | 4°C, protect from light, stored under nitrogen | | solubility | DMSO : 170 mg/mL (460.83 mM; Need ultrasonic) | | form | Solid | | color | White to yellow |
| | KH 176
(KH176) Usage And Synthesis |
| Uses | Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders[1]. | | in vivo | Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4 / mice[1].
| Animal Model: | Ndufs4/ mice (Leigh Disease model)[1].
| | Dosage: | 10mg/kg. | | Administration: | IP, daily (PD14-PD45, 32 days). | | Result: | Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells.
Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.
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| | References | [1] Ria de Haas, et al. Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease. Sci Rep. 2017 Sep 15;7(1):11733. DOI:10.1038/s41598-017-09417-5 |
| | KH 176
(KH176) Preparation Products And Raw materials |
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