FR 167653 FREE BASE
| 中文名称 | FR 167653 FREE BASE |
|---|---|
| 中文同义词 | 化合物 T11327L;化合物 FR 167653 FREE BASE |
| 英文名称 | FR-167653 |
| 英文同义词 | FR 167653 free base;1,2-Ethanedione, 1-[7-(4-fluorophenyl)-3,4-dihydro-8-(4-pyridinyl)pyrazolo[5,1-c][1,2,4]triazin-2(1H)-yl]-2-phenyl- |
| CAS号 | 158876-65-4 |
| 分子式 | C24H18FN5O2 |
| 分子量 | 427.43 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 158876-65-4.mol |
| 结构式 |  |
FR 167653 FREE BASE 性质
| 沸点 | 583.9±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.38±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3+-.0.10(Predicted) |
FR 167653 free base 是具有口服活性的，选择性 p38 MAPK 抑制剂，通过特异性抑制 p38 MAPK 活性抑制 TNF-α 和 IL-1β 生成。FR 167653 free base 可用于体内炎症，减轻创伤和缺血/再灌注损伤。
FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis.
| Animal Model: | Inbred male Balbuc mice (aged 8 weeks) |
| Dosage: | 32 mg/kg |
| Administration: | Subcutaneous injection; 24-48 hours |
| Result: | The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla. |