| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
F-1 manufacturers
- F-1
-
- $40.00
-
2026-07-27
- CAS:2244775-31-1
- Purity: 99.50%
- Supply Ability: 10g
- F-1
-
- $40.00
-
2026-07-27
- CAS:2244775-31-1
- Purity: 99.50%
- Supply Ability: 10g
|
| Product Name: | F-1 | | Synonyms: | Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-;ALK tyrosine kinase receptor,CD246,Anaplastic lymphoma kinase (ALK),F-1,Anaplastic lymphoma kinase,Inhibitor,F1,ROS Kinase,Cluster of differentiation 246,F 1,inhibit;N-{2-[(5-chloro-2-{[2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide;F-1, 10 mM in DMSO | | CAS: | 2244775-31-1 | | MF: | C22H27ClN8O3S | | MW: | 519.02 | | EINECS: | | | Product Categories: | | | Mol File: | 2244775-31-1.mol |  |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| Uses | F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1]. | | References | [1] Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333. DOI:10.1016/j.ejmech.2018.09.012 |
| | F-1 Preparation Products And Raw materials |
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