| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
- NH125
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- $34.00
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2026-08-20
- CAS:278603-08-0
- Purity: 98.60%
- Supply Ability: 10g
- NH125
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2026-08-07
- CAS:278603-08-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| Product Name: | NH125 | | Synonyms: | eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem;EEF-2 KINASE INHIBITOR;1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125;NH125 USP/EP/BP;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK;NH 125, CaMK III inhibitor | | CAS: | 278603-08-0 | | MF: | C27H45N2.I | | MW: | 524.567 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 278603-08-0.mol |  |
| | NH125 Chemical Properties |
| Melting point | 88.2-94.9 °C | | storage temp. | -20°C | | solubility | DMSO: 20 mg/mL | | form | solid | | color | white to off-white | | InChI | 1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1 | | InChIKey | RVWOHCBHAGBLLT-UHFFFAOYSA-M | | SMILES | [I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | NH125 Usage And Synthesis |
| Uses | NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus. | | Biological Activity | Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo . | | Biochem/physiol Actions | NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase. | | IC 50 | CaMK III: 60 nM (IC50) | | storage | Desiccate at -20°C | | references | [1]. arora, s., et al., identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. cancer res, 2003. 63(20): p. 6894-9.
[2]. cheng, y., et al., integrated regulation of autophagy and apoptosis by eef2k controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. autophagy, 2013. 9(2): p. 208-19.
[3]. usui, t., et al., eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. am j physiol heart circ physiol, 2013. 305(5): p. h756-68. |
| | NH125 Preparation Products And Raw materials |
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