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| Product Name: | LIMK1 antibody | | Synonyms: | LIMK1 antibody;Rabbit Monoclonal LIMK1 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![LIMK1 antibody Structure]() |
| | LIMK1 antibody Chemical Properties |
| | LIMK1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | LIM kinases are serine/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their amino-terminal regulatory domains. LIM kinases are involved in actin cytoskeletal regulation downstream of Rho-family GTPases, PAKs, and ROCK. PAK1 and ROCK phosphorylate LIMK1 or LIMK2 at the conserved Thr508 or Thr505 residues in the activation loop, increasing LIMK activity. Activated LIM kinases inhibit the actin depolymerization activity of cofilin by phosphorylation at the amino-terminal Ser3 residue of cofilin. | | References | [1] Okano, I. et al. (1995) J. Biol. Chem. 270, 31321-31330.
[2] Maekawa, M. et al. (1999) Science 285, 895-898.
[3] Edwards, D. C. et al. (1999) Nat. Cell Biol. 1, 253-259.
[4] Ohashi, K. et al. (2000) J. Biol. Chem. 275, 3577-3582.
[5] Sumi, T. et al. (2001) J. Biol. Chem. 276, 670-676.
[6] Arber, S. et al. (1998) Nature 393, 805-809.
[7] Yang, N. et al. (1998) Nature 393, 809-812. |
| | LIMK1 antibody Preparation Products And Raw materials |
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