TM6089 manufacturers
- TM6089
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- $30.00
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2026-08-08
- CAS:863421-32-3
- Purity: 99.70%
- Supply Ability: 10g
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| Product Name: | TM6089 | | Synonyms: | TM6089;TM6089,TM-6089;TM6089, 10 mM in DMSO;2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-5-[2-(2-pyridinylthio)acetyl]- | | CAS: | 863421-32-3 | | MF: | C13H14N4O3S | | MW: | 306.34 | | EINECS: | | | Product Categories: | | | Mol File: | 863421-32-3.mol |  |
| | TM6089 Chemical Properties |
| Boiling point | 465.5±55.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 2.25±0.19(Predicted) | | color | Light yellow to light brown |
| | TM6089 Usage And Synthesis |
| Uses | TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector[1]. | | References | [1] Nangaku M, et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2548-54. DOI:10.1161/ATVBAHA.107.148551 |
| | TM6089 Preparation Products And Raw materials |
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