5,6-DIMETHYL-2-THIOURACIL manufacturers
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| | 5,6-DIMETHYL-2-THIOURACIL Basic information |
| Product Name: | 5,6-DIMETHYL-2-THIOURACIL | | Synonyms: | 5,6-dimethyl-2-sulfanylidene-1H-pyrimidin-4-one;5,6-dimethyl-2-thioxo-1H-pyrimidin-4-one;5,6-Dimethyl-2-thioxo-2,3-dihydropyrimidin-4(1H);2-Mercapto-5,6-dimethylpyrimidin-4(3H)-one;5,6-DIMETHYL-2-THIOURACIL;5,6-dimethyl-2-thio-uraci;5,6-Dimethyl-4-hydroxy-2-thiopyrimidine 95%;2-Mercapto-5,6-dimethylpyrimidine-4-ol | | CAS: | 28456-54-4 | | MF: | C6H8N2OS | | MW: | 156.21 | | EINECS: | | | Product Categories: | Building Blocks;Heterocyclic Compounds;Heterocyclic Building Blocks;Pyrimidines | | Mol File: | 28456-54-4.mol |  |
| | 5,6-DIMETHYL-2-THIOURACIL Chemical Properties |
| Melting point | 284-288 °C(lit.) | | density | 1.2069 (rough estimate) | | refractive index | 1.6490 (estimate) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 7.88±0.25(Predicted) | | form | solid | | color | White to Pale Yellow | | Water Solubility | 1.373g/L(25 ºC) | | InChI | 1S/C6H8N2OS/c1-3-4(2)7-6(10)8-5(3)9/h1-2H3,(H2,7,8,9,10) | | InChIKey | MEAKRQUSGACTFV-UHFFFAOYSA-N | | SMILES | CC1=C(C)C(=O)NC(=S)N1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | YQ9887000 | | HazardClass | IRRITANT | | HS Code | 2933599590 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5,6-DIMETHYL-2-THIOURACIL Usage And Synthesis |
| Description | 5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones. It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma. | | Uses | 5,6-Dimethylthiouracil is a heterocyclic building block. | | References | [1] NAVROTSKII M B. Synthesis and Anti-HIV-1 Activity of New 2-[(2-Phthalimidoethyl)thio]-4(3H)-pyrimidinone Derivatives[J]. Pharmaceutical Chemistry Journal, 2005, 29 1: 466-467. DOI: 10.1007/s11094-006-0002-1
[2] SCHMIDT K S. In-house validation and factorial effect analysis of a liquid chromatography–tandem mass spectrometry method for the determination of thyreostats in bovine blood plasma[J]. Analytical and Bioanalytical Chemistry, 2013, 406 3: 735-743. DOI: 10.1007/s00216-013-7517-6 |
| | 5,6-DIMETHYL-2-THIOURACIL Preparation Products And Raw materials |
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