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| | N-(4-Bromophenyl)morpholine Basic information |
| | N-(4-Bromophenyl)morpholine Chemical Properties |
| Melting point | 114-118 °C (lit.) | | Boiling point | 341.2±37.0 °C(Predicted) | | density | 1.433±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 4.33±0.40(Predicted) | | color | White to Light yellow to Light orange | | InChI | InChI=1S/C10H12BrNO/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8H2 | | InChIKey | UJTKZWNRUPTHSB-UHFFFAOYSA-N | | SMILES | N1(C2=CC=C(Br)C=C2)CCOCC1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2934999090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | N-(4-Bromophenyl)morpholine Usage And Synthesis |
| Uses | N-(4-BROMOPHENYL)MORPHOLINE is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 
In an open flask, 10 mL of 1.5 M NaBr in pH 6.2 phosphate buffer (0.23 M in PO4) or pH 4.2 phosphate buffer (5% NaH2PO4) was added to a solution of 1 mmol of substrate dissolved in 9.75 mL of distilled 1,4- dioxane. To this mixture was added a freshly made solution of diphenyl ditelluride (1e, 0.25 mL of a 10 mM stock in 1,4-dioxane, 2.5 μmol, 0.25 mol % relative to substrate) followed by the addition of 8.8 M H2O2 according to Table 3. The reaction mixture was stirred at room temperature for the appropriate amount of time and was then diluted with 10 mL of water. The resulting solution was extracted with EtOAc (3 × 10 mL), and the combined organic extracts were washed with 0.5 M NaHSO3 (5 mL) and brine (10 mL), dried over MgSO4, and concentrated. Yields reported below are the mean of duplicate runs. N-(4-Bromophenyl)morpholine (21):28 product isolated as a tan solid (224 ± 1 mg, 93% yield). Mp 111-113 °C (lit.28 mp 111-112 °C). | | References | [1] Organic Letters, 2017, vol. 19, # 16, p. 4243 - 4246
[2] Journal of Chemical Research, 2014, vol. 38, # 10, p. 593 - 596
[3] Organic Letters, 2015, vol. 17, # 12, p. 2886 - 2889
[4] Synthesis, 2009, # 21, p. 3672 - 3676
[5] Synthetic Communications, 2010, vol. 40, # 19, p. 2954 - 2962 |
| | N-(4-Bromophenyl)morpholine Preparation Products And Raw materials |
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