| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
|
| | Prosaptide Tx 14(A) trifluoroacetate salt Basic information |
| | Prosaptide Tx 14(A) trifluoroacetate salt Chemical Properties |
| solubility | DMF: 1 mg/ml
DMSO: 1 mg/ml |
| | Prosaptide Tx 14(A) trifluoroacetate salt Usage And Synthesis |
| Description | Prosaptide TX14(A) is a peptide fragment of the neurotrophic factor prosaposin and an agonist of GPR37L1 and GPR37.1 It activates ERK signaling in HEK293T cells expressing GPR37L1 or GPR37 (EC50s = 5 and 7 nM, respectively) and inhibits forskolin-induced cAMP production in the same cells. Prosaptide TX14(A) (100 nM) protects primary mouse astrocytes from hydrogen peroxide-induced cell death. It reduces allodynia in a variety of rat peripheral pain models, including models of diabetic neuropathy and sciatic nerve hemiligation when administered at a dose of 4 mg/kg, as well as prevents paw allodynia induced by formalin at 1 mg/kg.2WARNING This product is not for human or veterinary use. | | References | [1] REBECCA C MEYER. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 23: 9529-9534. DOI: 10.1073/pnas.1219004110
[2] CORINNE G. JOLIVALT . Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia[J]. PAIN®, 2006, 121 1: Pages 14-21. DOI: 10.1016/j.pain.2005.11.013 |
| | Prosaptide Tx 14(A) trifluoroacetate salt Preparation Products And Raw materials |
|