|
|
| | TLQP 21 (trifluoroacetate salt) Basic information |
| | TLQP 21 (trifluoroacetate salt) Chemical Properties |
| solubility | Water: Sparingly soluble: 1-10 mg/ml |
| | TLQP 21 (trifluoroacetate salt) Usage And Synthesis |
| Description | TLQP 21 is a neuropeptide and fragment of the neurosecretory protein VGF (non-acronymic).1 It is produced by cleavage of pro-VGF by prohormone convertases. TLQP 21 selectively activates the complement C3a receptor (C3aR; EC50 = 83.6 nM in CHO cells expressing the human receptor) over C5a1 and C5a2 at 10 µM and induces phosphorylation of ERK1/2 in primary mouse bone marrow-derived macrophages (BMDMs), which endogenously express C3aR (EC50 = 96.5 nM). It also induces increases in intracellular calcium in primary mouse BMDMs, which can be inhibited by monoclonal antibodies targeting the globular C1q receptor (gC1qR).2 Intraplantar hind paw injection of TLQP 21-activated macrophages induces mechanical hypersensitivity in rats. TLQP 21 (25 µg/animal, i.c.v.) decreases food intake and body weight in hamsters.3 It also increases serum luteinizing hormone (LH) levels in pre-pubertal female rats when administered intraperitoneally but not intracerebroventricularly.4WARNING This product is not for human or veterinary use. | | References | [1] XARIA X LI. TLQP-21 is a low potency partial C3aR activator on human primary macrophages.[J]. Frontiers in Immunology, 2023, 14: 1086673. DOI: 10.3389/fimmu.2023.1086673
[2] YA-CHUN CHEN. Identification of a receptor for neuropeptide VGF and its role in neuropathic pain.[J]. The Journal of Biological Chemistry, 2013, 288 48: 34638-34646. DOI: 10.1074/jbc.m113.510917
[3] PREETI H JETHWA. VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters.[J]. Endocrinology, 2007, 148 8: 4044-4055. DOI: 10.1210/en.2007-0038
[4] ENRIQUE AGUILAR. Characterization of the reproductive effects of the Vgf-derived peptide TLQP-21 in female rats: in vivo and in vitro studies.[J]. Neuroendocrinology, 2013, 98 1: 38-50. DOI: 10.1159/000350323 |
| | TLQP 21 (trifluoroacetate salt) Preparation Products And Raw materials |
|