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Genistin

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CAS:529-59-9
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  • Genistin
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  • 2026-01-31
  • CAS:529-59-9
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  • Genistin
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  • Genistin
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  • $10.00 / 1kg
  • 2025-06-13
  • CAS:529-59-9
  • Min. Order: 1kg
  • Purity: 60% 80% 90% 95%
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Genistin Basic information
Product Name:Genistin
Synonyms:4',5,7-TRIHYDROXYISOFLAVONE 7-GLUCOSIDE;7-O-B-D-GLUCOPRYANOSYL GENISTEIN;7-O-BETA-D-GLUCOPYRANOSIDE;GENISTEIN-7-GLUCOSIDE;GENISTEIN, 7-O-BETA-D-GLUCOPYRANOSIDE;GENISTEIN-7-O-GLUCOSIDE;GENISTIN;GLUCOSYL-7-GENISTEIN
CAS:529-59-9
MF:C21H20O10
MW:432.38
EINECS:610-921-5
Product Categories:Iso-Flavones;The group of Daidzin;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;inhibitor;Aromatics;Glucuronides;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:529-59-9.mol
Genistin Structure
Genistin Chemical Properties
Melting point 254°C
alpha D21 -28° (c = 0.6 in 0.02N NaOH); D26 -21.4° (pyridine)
Boiling point 256 °C
density 1.642±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 10 mg/mL
pka6.12±0.20(Predicted)
form Solid
color Off-white
biological sourceGlycine max (soybean)
Merck 13,4402
BRN 64479
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Major Applicationfood and beverages
Cosmetics Ingredients FunctionsANTIOXIDANT
SKIN CONDITIONING
InChIKeyZCOLJUOHXJRHDI-CMWLGVBASA-N
SMILESOC[C@H]1O[C@@H](Oc2cc(O)c3C(=O)C(=COc3c2)c4ccc(O)cc4)[C@H](O)[C@@H](O)[C@@H]1O
LogP0.790 (est)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS DJ3093000
10
HS Code 29389090
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
Genistin Usage And Synthesis
DescriptionGenistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo.
Chemical PropertiesWhite Powder
UsesA derivative of Genistein. Inhibitor
UsesAn isoflavone glycoside which is an inactive analog of the PTK inhibitor Genistein.
UsesGenistin has been used for immune reactivity against influenza viruses in vitro and as an internal standard in isoflavones quantification.
UsesGlucoside of genistein that inhibits protein tyrosine kinase
DefinitionChEBI: Genistein 7-O-beta-D-glucoside is a 7-hydroxyisoflavones 7-O-beta-D-glucoside. It is functionally related to a genistein. It is a conjugate acid of a genistein 7-O-beta-D-glucoside(1-).
General DescriptionGenistin belongs to the class of isoflavone glycosides generally extracted from soybeans.
Biochem/physiol ActionsSelective inhibitor of mammalian terminal deoxynucleotidyl transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases.
Purification MethodsGenistin is repeatedly crystallised from hot 80% EtOH/water and treated with charcoal (Nuchar) until free from saponin. The presence of saponin is detected by adding crystals to conc H2SO4 when the citron yellow colour changes to red, then purple. Pure genistin does not change colour. UV in 85% EtOH has max at 262.5nm. [Walter J Am Chem Soc 63 3273 1941, Beilstein 18 III/IV 2732.]
References[1] YUKINOBU UCHIYAMA . Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): Baicalin and genistin[J]. Biochimica et biophysica acta. General subjects, 2005, 1725 3: Pages 298-304. DOI:10.1016/j.bbagen.2005.06.017
[2] EUN JEONG CHOI  Myeong S L  Taehee Kim. Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells[J]. Life sciences, 2007, 80 15: Pages 1403-1408. DOI:10.1016/j.lfs.2006.12.031
[3] ALESSANDRA RUSSO . Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells[J]. Journal of Nutritional Biochemistry, 2006, 17 2: Pages 103-108. DOI:10.1016/j.jnutbio.2005.05.011
Genistin Preparation Products And Raw materials
Preparation ProductsSophoricoside
Tag:Genistin(529-59-9) Related Product Information
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