盐酸塞利洛尔
| 中文名称 | 盐酸塞利洛尔 |
|---|---|
| 中文同义词 | 2,2,3,3,4,4,5,5,6-九溴联苯醚;得来恩;盐酸塞利洛尔;3-[3-乙酰-4-(3-叔丁胺基)-2-羟基丙氧基]苯基-1,1-二乙基脲盐酸盐;塞利洛尔峰鉴别 EP标准品;盐酸塞利洛尔 EP标准品;1-二氯乙烯;2-双(4-氯苯基)-1 |
| 英文名称 | Celiprolol hydrochloride |
| 英文同义词 | celiprololhydrochlorid;3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea hydrochloride;CELIPROLOL HYDROCHLORIDE;Celipolol Hydrochloride;3-[3-acetyl-4-[3-[(tert-butyl)amino]-2-hydroxypropoxy]phenyl]-1,1-diethyluronium chloride;Urea, N-3-acetyl-4-3-(1,1-dimethylethyl)amino-2-hydroxypropoxyphenyl-N,N-diethyl-, monohydrochloride;CELIPOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE);Celectol |
| CAS号 | 57470-78-7 |
| 分子式 | C20H34ClN3O4 |
| 分子量 | 415.95 |
| EINECS号 | 260-752-2 |
| 相关类别 | 小分子抑制剂;盐酸塞利洛尔（标准品）;抑制剂;原料;医药原料药;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 57470-78-7.mol |
| 结构式 |  |
盐酸塞利洛尔 性质
| 熔点 | 197-200°C (dec.) |
|---|---|
| RTECS号 | YR6560000 |
| 储存条件 | Refrigerator |
| 溶解度 | 易溶于水和甲醇，溶于乙醇（96%），极微溶于二氯甲烷。 |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in ethanol, methanol and water |
| InChI | 1S/C20H33N3O4.ClH/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6;/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26);1H |
| InChIKey | VKJHTUVLJYWAEY-UHFFFAOYSA-N |
| SMILES | [Cl-].N(CC)(CC)C(=O)Nc1cc(c(cc1)OCC(O)CNC(C)(C)C)C(=O)C.[H+] |
| CAS 数据库 | 57470-78-7(CAS DataBase Reference) |
Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。
β1-andrenoceptor
Celiprolol (5 or 50 mg/kg; p.o. every day for 12 weeks) has a moderate antihypertensive action at the dose of 50 mg/kg, and significantly reduces media smooth muscle hypertrophy of the mesenteric artery in SHR.
| Animal Model: | Male spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats (8 weeks old) |
| Dosage: | 5, 50 mg/kg |
| Administration: | P.o. every day (administered in drinking water) for 12 weeks |
| Result: |
Attenuated the rise in blood pressure significantly at the dose of 50 mg/kg in SHR.
Did not significantly affect absolute heart or body weights. Reduced the average medial thickness of the mesenteric artery in SHR. |
用途
抗高血压药。安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 毒性 | LD50 in male mice, rats (mg/kg): 56.2, 68.3 i.v.; 1834, 3826 orally (Wendtlandt, Pittner) |
盐酸塞利洛尔 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S5923 | 盐酸塞利洛尔 Celiprolol hydrochloride | 57470-78-7 | 2mg | 795.34元 |
| 2026/03/03 | S5923 | 盐酸塞利洛尔 Celiprolol hydrochloride | 57470-78-7 | 10mg | 1777.23元 |