Benzeneacetonitrile, 3-chloro-2-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)- manufacturers
- JNJ-56022486
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- $2500.00
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2026-05-11
- CAS:2036082-79-6
- Purity:
- Supply Ability: 10g
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| | Benzeneacetonitrile, 3-chloro-2-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)- Basic information |
| | Benzeneacetonitrile, 3-chloro-2-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)- Chemical Properties |
| Boiling point | 392.4±42.0 °C(Predicted) | | density | 1.347±0.06 g/cm3(Predicted) | | pka | 11.79±0.30(Predicted) |
| | Benzeneacetonitrile, 3-chloro-2-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)- Usage And Synthesis |
| Description | JNJ-56022486 is an AMPA receptor modulator which is selective for TARP γ8. | | Uses | JNJ-56022486 is an orally active and potent negative AMPA receptor modulator (Ki=19 nM) selective forTARP-γ8. JNJ-56022486 is also a TARP-γ8 receptor antagonist, with bloodbrainbarrier (BBB) permeability. JNJ-56022486 can be used for research of Epilepsy[1][2]. | | References | [1] Maher MP, et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016 May;357(2):394-414. DOI:10.1124/jpet.115.231712
[2] Rosenbaum MI, et al. Targeting receptor complexes: a new dimension in drug discovery. Nat Rev Drug Discov. 2020 Dec;19(12):884-901. DOI:10.1038/s41573-020-0086-4 |
| | Benzeneacetonitrile, 3-chloro-2-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)- Preparation Products And Raw materials |
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