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| | 5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Basic information |
| | 5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Chemical Properties |
| Boiling point | 634.1±65.0 °C(Predicted) | | density | 1.211±0.06 g/cm3(Predicted) | | solubility | Chloroform: 10 mg/ml; Ethanol: 10 mg/ml; Methyl Acetate: 1 mg/ml | | pka | 2.61±0.10(Predicted) |
| | 5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Usage And Synthesis |
| Description | 5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).1 It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 μM. It also inhibits LPS-induced prostaglandin E2 (PGE2; ) production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats. | | Uses | mPGES1-IN-4 (compound 32) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo. | | References | 1. Kalic, F., Kolman, V., Ajani, H., et al. Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edema ChemMedChem 15(15),1398-1407(2020). |
| | 5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Preparation Products And Raw materials |
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