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| | N-tert-Butyl-alpha-phenylnitrone Basic information |
| | N-tert-Butyl-alpha-phenylnitrone Chemical Properties |
| Melting point | 73-74 °C(lit.) | | Boiling point | 283℃ | | density | 0.990 | | refractive index | 1.5480 (estimate) | | Fp | 119℃ | | storage temp. | Store at <= 20°C. | | solubility | DMSO: soluble | | form | powder | | pka | 1.50±0.53(Predicted) | | color | white | | Water Solubility | Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml). | | Merck | 14,7056 | | BRN | 2044028 | | Cosmetics Ingredients Functions | ANTIOXIDANT | | InChI | 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9- | | InChIKey | IYSYLWYGCWTJSG-XFXZXTDPSA-N | | SMILES | CC(C)(C)[N+](\[O-])=C\c1ccccc1 | | CAS DataBase Reference | 3376-24-7(CAS DataBase Reference) | | EPA Substance Registry System | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | TX1760000 | | F | 10 | | TSCA | TSCA listed | | HS Code | 2929 90 00 | | Storage Class | 11 - Combustible Solids |
| | N-tert-Butyl-alpha-phenylnitrone Usage And Synthesis |
| Chemical Properties | white to light beige fine crystalline powder | | Uses | Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals. | | Uses | N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species. | | Uses | N-tert-Butyl-α-phenylnitrone has been used:
- as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
- as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
- to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)
| | Synthesis Reference(s) | Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6 | | General Description | Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species. | | Biochem/physiol Actions | Product does not compete with ATP. | | Purification Methods | Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.] |
| | N-tert-Butyl-alpha-phenylnitrone Preparation Products And Raw materials |
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Tag:N-tert-Butyl-alpha-phenylnitrone(3376-24-7)
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