S-(hydrogen malonyl)coenzyme A manufacturers
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| | S-(hydrogen malonyl)coenzyme A Basic information |
| Product Name: | S-(hydrogen malonyl)coenzyme A | | Synonyms: | Malonyl Coenzyme A;coenzyme A malonyl derivative, tetralithium salt;Adenosine 5'-[diphosphoric acid β-[(R)-4-[[2-[[2-(carboxyacetylthio)ethyl]carbamoyl]ethyl]amino]-4-oxo-3-hydroxy-2,2-dimethylbutyl]]3'-phosphoric acid;S-(Carboxyacetyl)coenzyme A;malony-coa;S-(hydrogen malonyl)coenzyme A;Coenzyme A, S-(hydrogen propanedioate);3-[2-[3-[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]aminopropanoylamino]ethylsulfanyl]-3-oxo-propanoic acid | | CAS: | 524-14-1 | | MF: | C24H38N7O19P3S | | MW: | 853.58 | | EINECS: | 208-353-4 | | Product Categories: | | | Mol File: | 524-14-1.mol |  |
| | S-(hydrogen malonyl)coenzyme A Chemical Properties |
| density | 1.95±0.1 g/cm3(Predicted) | | pka | 1.16±0.50(Predicted) |
| | S-(hydrogen malonyl)coenzyme A Usage And Synthesis |
| Uses | Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2]. | | Definition | ChEBI: The S-malonyl derivative of coenzyme A. | | IC 50 | Human Endogenous Metabolite | | References | [1] Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. DOI:10.1016/j.cardiores.2006.10.008
[2] Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. DOI:10.1006/bbrc.2001.5146
[3] Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6. DOI:10.1042/bj2100953 |
| | S-(hydrogen malonyl)coenzyme A Preparation Products And Raw materials |
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