bamifylline hydrochloride manufacturers
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| | bamifylline hydrochloride Basic information |
| Product Name: | bamifylline hydrochloride | | Synonyms: | bamifylline hydrochloride;BAMIPHYLLINE HCL (GMP);BAMIPHYLLINE HCL;Bamiphyllinehydrochloride;AC-3810;Trentadil;1H-Purine-2,6-dione, 7-(2-(ethyl(2-hydroxyethyl)amino)ethyl)-3,7-dihydro-1,3-dimethyl-8-(phenylmethyl)-, monohydrochloride;7-(N-(beta-Hydroxyethyl)-N-ethyl)-aminoethyl-8-benzyl-theophylline hydrochloride | | CAS: | 20684-06-4 | | MF: | C20H27N5O3.ClH | | MW: | 421.926 | | EINECS: | 243-967-6 | | Product Categories: | | | Mol File: | 20684-06-4.mol |  |
| | bamifylline hydrochloride Chemical Properties |
| Toxicity | LD50 in mice, rats (mg/kg): 246, 1139 orally; 89, 131 i.p.; 67, 65 i.v. (Georges) |
| | bamifylline hydrochloride Usage And Synthesis |
| Originator | Bamifylline,ZYF Pharm Chemical | | Uses | Bronchodilator. | | Manufacturing Process | A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300
L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24
hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture
was refluxed. After cooling to the mixture was added the water and
hydrochloric acid. The organic phase was extracted with hydrochloric acid. The
acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β-
hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with
dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl-
N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol.
Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline
was obtained by addition to the solution the hydrochloric acid; yield 81%,
melting point 185-186°C. | | Therapeutic Function | Bronchodilator, Coronary vasodilator |
| | bamifylline hydrochloride Preparation Products And Raw materials |
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