3-Hydroxythiophene-2-carboxylic acid manufacturers
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| | 3-Hydroxythiophene-2-carboxylic acid Basic information |
| | 3-Hydroxythiophene-2-carboxylic acid Chemical Properties |
| Melting point | 108 °C(Solv: acetone (67-64-1)) | | Boiling point | 326.4±27.0 °C(Predicted) | | density | 1.603±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | form | crystalline powder | | pka | 3.79±0.10(Predicted) | | color | Brown/grey |
| Hazard Codes | Xi | | HS Code | 2934999090 |
| | 3-Hydroxythiophene-2-carboxylic acid Usage And Synthesis |
| Uses | 3-Hydroxythiophene-2-carboxylic acid (cas# 5118-07-0) is a useful research chemical. This compound is useful because furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site. | | Synthesis | General procedure for the synthesis of 3-hydroxythiophene-2-carboxylic acid from 3-benzyloxythiophene-2-carboxylic acid: a) 3-benzyloxythiophene-2-carboxylic acid (1.0 g) was hydrogenated with 10% palladium-carbon catalyst (1.8 g) in a mixture of ethanol (150 mL) and 2N hydrochloric acid (4.5 mL) for 2 hours at 45 psi hydrogen pressure. Upon completion of the reaction, the mixture was filtered through a layer of diatomaceous earth and the filtrate was concentrated under vacuum to afford 3-hydroxythiophene-2-carboxylic acid (600 mg, 98% yield) as an off-white solid product. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 6.78 (d, 1H), 7.49 (d, 1H). Mass spectrometry (APCI) showed m/z=145 (M+1).LC/MS analysis showed a retention time of 1.15 min. | | References | [1] Patent: WO2007/1225, 2007, A1. Location in patent: Page/Page column 16 |
| | 3-Hydroxythiophene-2-carboxylic acid Preparation Products And Raw materials |
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