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Postion:Product Catalog > Almitrine dimesylate
Almitrine dimesylate
  • Almitrine dimesylate
  • Almitrine dimesylate

Almitrine dimesylate NEW

Price $10 $5 $1
Package 1kg 25kg 100kg
Min. Order: 1kg
Supply Ability: g-kg-tons, free sample is available
Update Time: 2025-09-25
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Product Details

Product Name: Almitrine dimesylate CAS No.: 29608-49-9
Min. Order: 1kg Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2025/09/25
Lead time: In stock, ready for shipment PACKAGING: bag/bottle/drum/IBC
COA, MSDS: Available, contact us for details Origin: Manufacturer, advantage product
Delivery : By express, by air, by sea NAME: Sun

1. Materials information

Names

Namealmitrine dimesylate
SynonymMore Synonyms

 Almitrine dimesylate Biological Activity

DescriptionAlmitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel.
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Research Areas >> Cardiovascular Disease
Research Areas >> Neurological Disease
Target

K+ channel[1]

In VitroAlmitrine inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+ channel by decreasing its open probability. The IC50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca2+-dependent K+ channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca2+-dependent component of K+ currents in rat chemoreceptor cells[1].
In VivoAlmitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio[2].
Animal AdminRats[2] 8-week-old male spf Wistar rats are used. Rats are anaesthetized with Thiobarbiturate inactin (BYK, 100 mg/kg, i.p.). The interaction of the ventilatory response to hypoxia and an intermittent (2 min on, 1 min break) low-dose (10 μg/kg per min) and high-dose (80 μg/kg per min) infusion of S9581 or Almitrine is tested in control and chronically hypoxic rats. S9581 or Almitrine is infused intravenously (100 μg/ mL). Inspired oxygen levels were controlled by passing oxygen-nitrogen mixtures across the tracheal port at a flow rate of 3-41 min-1[2].
References

[1]. López-López JR, et al. Effects of Almitrine bismesylate on the ionic currents of chemoreceptor cells from the carotid body. Mol Pharmacol. 1998 Feb;53(2):330-9.

[2]. Bee D, et al. An analysis of the action of an analogue of Almitrine bismesylate in the rat model of hypoxic lung disease. Exp Physiol. 1992 Nov;77(6):819-28.

 Chemical & Physical Properties

Boiling Point606.2ºC at 760 mmHg
Molecular FormulaC28H37F2N7O6S2
Molecular Weight669.763
Exact Mass669.221497
PSA194.71000
LogP5.57570
Vapour Pressure1.21E-14mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • XY5850250

  • CHEMICAL NAME :

  • 1,3,5-Triazine-2,4-diamine, 6-(4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-N,N'- di-2- propenyl-, dimethanesulfonate

  • CAS REGISTRY NUMBER :

  • 29608-49-9

  • LAST UPDATED :

  • 199112

  • DATA ITEMS CITED :

  • 3

  • MOLECULAR FORMULA :

  • C26-H29-F2-N7.2C-H4-O3-S

  • MOLECULAR WEIGHT :

  • 669.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >2 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 28,814,1972

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 370 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 3,363,1972

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 207 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 3,363,1972

 Synonyms

S2620 bismethanesulfonate
ALMITRINE DIMESILATE
6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-N,N'-di(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine methanesulfonate (1:2)
S 2620 bismethanesulfonate
1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N-di-2-propen-1-yl-, methanesulfonate (1:2)
N,N'-Diallyl-6-{4-[bis(4-fluorophenyl)methyl]-1-piperazinyl}-1,3,5-triazine-2,4-diamine methanesulfonate (1:2)
ALMITRINE BISMESYLATE
Almitrine dimethanesulfonate
Almitrine mesylate
N,N'-Diallyl-6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-1,3,5-triazine-2,4-diamine methanesulfonate (1:2)
1,3,5-Triazine-2,4-diamine, 6-(4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-N,N'-di-2-propenyl-, dimethanesulfonate
N,N'-Diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine dimethanesulphonate
n,n'-diallyl-6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1,3,5-triazine-2,4-diamine dimethanesulphonate
2,4-bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine dimethanesulfonate
Almitrine dimesylate
Top Suppliers:I want be here

  • DC Chemicals Limited

  • China

  • Product Name: Vectarion

  • Price:$Inquiry/100mg$Inquiry/250mg$Inquiry/500mg

  • Purity: 98.0%

  • Stocking Period: 3 Day

  • Contact: Tony Cao

  • Dayang Chem (Hangzhou) Co., Ltd.

  • China

  • Product Name: Almitrine dimesylate

  • Price:$Inquiry/100g$Inquiry/1kg$Inquiry/100kg$Inquiry/1000kg

  • Purity: 98.0%

  • Stocking Period: Inquiry

  • Contact: Ms Wang

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Almitrine dimesylate suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more Almitrine dimesylate price

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2. Packaging of materials

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  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


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4. Contact information

For more details, pls contact us freely.

Email address: sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 8613526505137


















Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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