Clindamycin hydrochloride NEW

Specification of Clindamycin hydrochloride CAS 21462-39-5:

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Clindamycin hydrochloride is a salt form of clindamycin, a lincosamide antibiotic. It is a semi-synthetic derivative of lincomycin, designed for better absorption and bioavailability, primarily formulated for oral administration (capsules, oral solution).

Primary Mechanism of Action

• Bacteriostatic: It inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome.

  Effective against aerobic gram-positive cocci and, critically, many anaerobic bacteria (both gram-positive and gram-negative).

Primary Uses (Indications)

Due to its excellent tissue penetration and anaerobic coverage, it is prescribed for:

1. Serious Anaerobic Infections: Especially below the diaphragm (e.g., intra-abdominal abscesses, peritonitis, endometritis).

2. Skin and Soft Tissue Infections: Caused by Staphylococcus aureus (including some MRSA strains) and streptococci.

3. Bone and Joint Infections: Particularly osteomyelitis caused by susceptible organisms.

4. Oral Infections: Used in dentistry for severe dental abscesses involving anaerobes.

5. Alternative to Penicillin: For patients with severe penicillin allergy, in conditions like tonsillitis or cellulitis.

6. Adjunct Therapy: Used with other drugs for infections like pelvic inflammatory disease (PID) or toxoplasmosis.

Crucial Warning & Side Effect

• Clostridioides difficile-Associated Diarrhea (CDAD): Its use significantly disrupts normal gut flora and is a major cause of severe, potentially life-threatening C. diff colitis. Use is reserved for cases where benefits outweigh this serious risk.

Summary Table

Disclaimer: This is a prescription-only antibiotic. Its use requires a confirmed or strongly suspected bacterial infection susceptible to clindamycin, as misuse contributes to resistance and serious adverse effects. Always complete the prescribed course.

Package of Clindamycin hydrochloride CAS 21462-39-5:

Application of Clindamycin hydrochloride CAS 21462-39-5:

Clindamycin hydrochloride is a salt of clindamycin, a semi-synthetic lincosamide.  Like other members of the lincosamide family, clindamycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans.