Clonidine hydrochloride

Product Name: Clonidine hydrochloride

Synonyms: CLONIDINE HCL;CLONIDINE HYDROCHLORIDE;DIXARIT;2-[2,6-DICHLOROANILINE]-2-IMIDAZOLINE HYDROCHLORIDE;2-(2,6-DICHLOROANILINO)-2-IMIDAZOLINE, HCL;2-(2,6-DICHLOROANILINO)-2-IMIDAZOLINE HYDROCHLORIDE;2-(2,6-DICHLOROPHENYLAMINO)-2-IMIDAZOLINE HYDROCHLORIDE;katapresan

CAS: 4205-91-8

MF: C9H10Cl3N3

MW: 266.55

Melting point 312 °C

storage temp. 2-8°C

solubility H2O: 50 mg/mL, clear, colorless

form solid

color white

PH pH(50g/l, 25℃) : 3.5～6.0

Water Solubility Soluble in water (50 mg/ml), DMSO (75 mM), methanol, chloroform (slightly), and dehydrated alcohol.

Merck 14,2390

General Description

Clonidine hydrochloride, 2-[(2,6-dichlorophenyl)imino]imidazolidine monohydrochloride(Catapres), was the first antihypertensive known to acton the CNS. It was synthesized in 1962 as a derivativeof the known -sympathomimetic drugs naphazoline andtolazoline, potential nasal vasoconstrictors, but instead itproved to be effective in the treatment of mild-to-severe hypertension.Clonidine hydrochloride acts by both peripheral andcentral mechanisms in the body to affect blood pressure. Itstimulates the peripheral -adrenergic receptors to producevasoconstriction, resulting in a brief period of hypertension.