Ritalinic acid NEW

Ritalinic acid Cas 19395-41-6

Specification

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Ritalinic Acid is the primary, inactive metabolite of the stimulant drug methylphenidate (commonly known by the brand name Ritalin®).

Here's a breakdown of what it is and its relevance:

What It Is

• Origin: When a person takes methylphenidate (for ADHD or narcolepsy), the body's liver enzymes rapidly break it down.

  Process: This breakdown (hydrolysis) removes the methyl ester from the methylphenidate molecule, producing ritalinic acid.

  Key Point: Unlike its parent compound, ritalinic acid has little to no stimulant effect on the central nervous system. It is considered pharmacologically inactive.

Primary Use & Significance

Ritalinic acid itself is not a medication and has no direct therapeutic use. However, it is critically important for two main reasons:

1. Drug Testing and Detection:

• This is its most significant practical application. Ritalinic acid is the primary marker used in urine drug tests to determine if someone has taken methylphenidate.

  It has a much longer detection window (typically 1-2 days) in urine than the active parent drug, making it the ideal target for testing.

2. Pharmacokinetic Research:

• Studying the levels of ritalinic acid in the blood or urine helps researchers and doctors understand how an individual metabolizes methylphenidate.

  The ratio and speed of conversion from methylphenidate to ritalinic acid can influence the drug's duration and effectiveness, which is relevant for optimizing ADHD treatment.

Important Distinction

• Methylphenidate (Ritalin®): The active prescription drug used to treat ADHD and narcolepsy. It works by increasing dopamine and norepinephrine in the brain to improve focus and attention.

  Ritalinic Acid: The inactive breakdown product that the body creates and excretes.

Summary

Ritalinic acid is not a drug you would ever be prescribed. It is the inert result of the body processing the ADHD medication methylphenidate. Its sole "use" is as a diagnostic and forensic tool for detecting the use of methylphenidate in medical, employment, or legal settings.

Disclaimer: This information is for educational purposes. Methylphenidate is a controlled substance available only by prescription.

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