Losartan potassium NEW

Specification of Losartan potassium CAS 124750-99-8:

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Losartan Potassium is the potassium salt of Losartan, an angiotensin II receptor antagonist (ARB) used primarily as an antihypertensive drug. Chemically, it is an organic molecule containing a biphenyl tetrazole group.

Uses in Chemical/Pharmaceutical Contexts:

1. Active Pharmaceutical Ingredient (API): It is the final, isolated drug substance. Chemical processes focus on its synthesis, purification, and salt formation (converting Losartan acid to the potassium salt to enhance solubility and stability).

2. Solid-State Chemistry: Controlling its crystalline form is critical. Chemists ensure consistent production of a therapeutically effective and stable polymorph, as different solid forms can affect dissolution rates and bioavailability.

3. Analytical Reference Standard: Highly purified Losartan potassium is used as a calibration standard in analytical chemistry (e.g., HPLC, UV spectroscopy) to assay drug purity, potency, and stability in formulations and for quality control.

4. Formulation Studies: In pre-formulation, chemists study its compatibility with excipients and its physicochemical properties (hygroscopicity, solubility, pH stability) to develop stable tablet or suspension formulations.

5. Metabolism Studies: It is used in research as a substrate to study its biotransformation into its active metabolite (E-3174) and other pathways, which is essential for understanding its pharmacokinetics.

Package of Losartan potassium CAS 124750-99-8:

Application of Losartan potassium CAS 124750-99-8:

Antihypertensive, used to treat hypertension.