
Product Details
Product Name: Antipyrine | CAS No.: 60-80-0 |
EC-No.: 246-386-6 | Min. Order: 1g |
Purity: 99% | Supply Ability: 5ton/month |
Release date: 2025/09/28 |
Antipyrine (also known as phenazone) is a synthetic pyrazolone derivative with the following key characteristics:
Historical Use: Developed in the 1880s, it was one of the first widely used synthetic analgesics (pain relievers) and antipyretics (fever reducers).
Mechanism: Acts as a mild non-opioid analgesic and antipyretic, though its exact mechanism is less defined than modern NSAIDs (e.g., it weakly inhibits prostaglandin synthesis).
Current Status: Largely obsolete for systemic use (oral/parenteral) due to:
Risk of Agranulocytosis: A potentially life-threatening drop in white blood cells.
Skin Reactions: Risk of rashes and hypersensitivity.
Availability of Safer Alternatives: Like paracetamol (acetaminophen) and ibuprofen.
Modern Applications:
Otology: A common active ingredient in ear drops (e.g., Auralgan) combined with benzocaine. It reduces inflammation and pain associated with otitis media/externa.
Research: Used as a marker compound to measure cytochrome P450 enzyme activity in drug metabolism studies (the "antipyrine test").
Chemistry: White crystalline powder (C₁₁H₁₂N₂O), structurally related to aminophenazone (aminopyrine) and metamizole.
In short: Antipyrine is a historical analgesic/antipyretic now primarily used topically in ear drops for earache and as a research tool in pharmacology. Its systemic use is discontinued due to safety concerns.
Company Profile Introduction
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- Since: 2006-04-03
- Address: Room 2015, No.2 Building Kaixin Mansion, No.107 Jinqiao Ave, Wuhan, China
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