Methotrexate NEW

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Specification

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Product Name:Methotrexate

CAS:59-05-2

MF:C20H22N8O5

Melting point :195°C
form:powder
color:Yellow crystalline

Uses:

Methotrexate is a classic antifolate metabolic drug that primarily exerts dual effects as an anti-tumor and immunosuppressive agent in clinical practice.

Its core selling points lie in its broad-spectrum versatility across multiple medical fields and its highly cost-effective nature, making it a cornerstone medication in rheumatology/immunology and oncology.

Core Pharmacological Mechanism

Methotrexate works by inhibiting the enzyme dihydrofolate reductase, which blocks folate metabolism within cells. This interferes with the synthesis of DNA and RNA. This mechanism effectively suppresses rapidly proliferating cells, whether they are cancer cells or overactive immune cells.

Main Clinical Applications

Autoimmune Diseases: Such as rheumatoid arthritis and psoriasis. In these conditions, it serves as an "anchor drug," effectively suppressing immune responses, controlling joint pain and swelling, and delaying bone destruction.

Malignant Tumor Treatment: Widely used for acute leukemias, choriocarcinoma, osteosarcoma, and head and neck cancers. In these cases, high-dose regimens are typically used to directly kill tumor cells.

Other Fields: Under specific circumstances, it can also be used for the conservative treatment of ectopic pregnancy, stopping embryonic development by inhibiting cell proliferation.

Core Selling Points & Clinical Advantages

Proven Efficacy & Rapid Onset: As the "gold standard" for treating rheumatoid arthritis, its efficacy has been validated by decades of large-scale clinical trials. When administered via injection, it typically takes effect within 1 to 2 days.

Exceptional Cost-Effectiveness: As a well-established older drug, methotrexate is very inexpensive, greatly reducing the long-term financial burden on patients.

Flexible Administration: It is available in oral tablet forms and various injectable forms (intravenous, intramuscular, subcutaneous, or intrathecal injection), allowing for flexible dosing regimens tailored to different conditions and patient absorption rates.

Key Precautions & Side Effect Management

Differences in Dosing Frequency: Cancer treatment often involves daily or cyclical high-dose administration; whereas treating rheumatoid arthritis typically requires taking or injecting the medication only once a week. Confusing these frequencies can lead to severe toxicity.

Common Adverse Reactions: Include gastrointestinal issues like nausea and vomiting, as well as elevated liver enzymes and bone marrow suppression (decreased white blood cells or platelets).

Safety Measures: Clinically, folic acid supplementation is often used to effectively mitigate gastrointestinal and liver-related side effects. Meanwhile, patients must strictly avoid alcohol and undergo regular monitoring of liver function and complete blood counts.

Methotrexate is a classic drug with a clear mechanism, broad applications, and exceptional cost-effectiveness. Despite potential side effects, it holds irreplaceable clinical value in controlling autoimmune diseases and tumors when used strictly according to guidelines and with regular monitoring.

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FAQ From Wuhan Fortuna Chemical Co.,Ltd

Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.

Q6: How do you treat quality complaint ?

A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

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