Sodium gualenate NEW

Sodium gualenate Cas 6223-35-4

Specification

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Sodium Gualenate is a man-made (synthetic) chemical compound primarily used for its anti-inflammatory properties. It's not a well-known household name because you'll most commonly find it as an active ingredient in prescription eye drops and some topical ointments in certain countries, particularly Japan and other parts of Asia.

Think of it as a medicine that helps reduce swelling, redness, and irritation.

Detailed Breakdown

1. What It Is Chemically

Chemically, Sodium Gualenate is known as a azulene sulfonate derivative. Azulene is a classic organic compound known for its beautiful blue color and anti-inflammatory properties (it's found in chamomile oil, for instance). Sodium Gualenate is a more stable, synthesized version designed for medicinal use.

2. How It Works (Mechanism of Action)

The primary way Sodium Gualenate works is by stabilizing cell membranes. Here's a simpler way to understand that:

• Inflammation Process: When cells are damaged or irritated (e.g., by allergens, dust, or infection), they release chemicals called prostaglandins and leukotrienes. These are like "inflammatory signals" that cause blood vessels to leak, leading to swelling, redness, and pain.

  Sodium Gualenate's Role: It helps "shore up" the membranes of cells (like mast cells), making them less likely to rupture and release those inflammatory signals. By doing this, it acts as an anti-inflammatory agent and a very mild antiallergic agent.

It is not a steroid. This is a key point, as it offers an alternative for patients who need to avoid steroid-based medications.

3. Primary Uses and Applications

Sodium Gualenate is most famously used in ophthalmology (eye care).

• Allergic Conjunctivitis: This is its most common use. It is effective in treating the itchy, red, and watery eyes caused by allergies to pollen, pet dander, etc.

  Other Eye Inflammations: It is also used for general anti-inflammatory purposes after eye surgery or to treat non-allergic conjunctivitis.

You might also find it in some topical creams or gargles for treating minor mouth or skin inflammations, but this is less common.

4. Common Brand Names

You will typically encounter Sodium Gualenate as an ingredient in products like:

• Pointel-A®: A well-known brand in Japan that combines Sodium Gualenate with other ingredients like Chlorpheniramine (an antihistamine).

  Other combination eye drops, where it is paired with antihistamines, vitamins, or other anti-inflammatory agents to provide a multi-pronged approach to relieving eye irritation.

5. Safety Profile

Sodium Gualenate is generally considered very safe with a low risk of side effects. Because it is a non-steroidal anti-inflammatory drug (NSAID), it avoids the potential side effects associated with long-term steroid use, such as increased intraocular pressure or cataracts.

Possible side effects are usually mild and localized, such as:

• Temporary stinging or irritation upon application.

  Blurred vision for a short time after using the eye drops.

As with any medication, it's essential to use it under the guidance of a doctor or pharmacist.

Key Takeaways

• What it is: A synthetic anti-inflammatory compound.

  Main Use: Prescription eye drops for allergic conjunctivitis.

  Key Feature: It is a non-steroidal anti-inflammatory, making it a good alternative to steroids.

  How it works: Stabilizes cell membranes to prevent the release of inflammatory chemicals.

  Common in: Japan and other Asian markets, less common in North America and Europe.

In short, if you come across Sodium Gualenate, you're looking at a specialized, effective, and generally safe medication for reducing inflammation, particularly in the eyes.

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* Wire Transfer/Telegraphic Transfer

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* L/C

Contact information

Spring Zhang

Email: export@fortunachem.com  

Skype: Fortunachem201304       

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Tel:   +86-27-59207892

Website: www.fortunachem.com