3-Deoxyglucosone NEW
| Price | $188 | $478 | Get Latest Price |
| Package | 1mg | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-20 |
Product Details
| Product Name: 3-Deoxyglucosone | CAS No.: 4084-27-9 |
| Purity: 95% | Supply Ability: 10g |
| Release date: 2025/07/20 |
Product Introduction
Bioactivity
| Name | 3-Deoxyglucosone |
| Description | 3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein amino groups to form advanced glycosylated end proteins (AGEs).3-Deoxyglucosone inactivates glutathione peroxidase and synergizes with low glucose to enhance GLP-1 secretion.3-Deoxyglucosone is used as a biomarker for diabetes mellitus.3-Deoxyglucosone has been shown to be an inhibitor of GLP-1 secretion in the presence of low glucose. 3-Deoxyglucosone inactivates glutathione oxidase, synergizes with low glucose to enhance GLP-1 secretion, and can be used as a biologic marker for diabetes. |
| Cell Research | Cell Line: STC-1 cells. Concentration: 300?ng/ml. Incubation Time: 1 hour [1] |
| Animal Research | Animal Model: SD rats. Dosage: 5, 20 and 50 mg/kg. Administration: oral administration; once daily; 2 weeks [3] |
| In vitro | 3-Deoxyglucosone (80 ng/ml-1000 ng/ml; 1 hour; STC-1 cells) induces a 1.23-fold increase in GLP-1 secretion at 300 ng/ml and 1000 ng/ml, while 80 ng/ml shows no effect. At 300 ng/ml, 3DG significantly elevates intracellular Ca2+ levels, as measured by Fluo-3/AM (2.5 μM for 30 mins), but does not affect intracellular cAMP in a cAMP Elisa assay. Additionally, 300 ng/ml 3DG significantly enhances TAS1R2, TAS1R3, and TRPM5 protein expression under both glucose-free and high conditions.[1] |
| In vivo | 3-Deoxyglucosone (20 mg/kg; intragastric administration; single dose) induces a deterioration in glucose tolerance, as evidenced by an increased Area Under the Curve (AUC). Plasma glucagon levels do not show significant differences. The administration of 3-Deoxyglucosone leads to the development of impaired glucose regulation (IGR) accompanied by evident dysfunction of pancreatic islet cells in both Kunming mice and SD rats.[2] 3-deoxyglucosone (5-50 mg/kg; gastric gavage; once daily; 2 weeks; SD rats) exhibits significant increases in the upper small intestine (1.4-fold), lower small intestine (1.4-fold), ileum (1.4-fold), and colon (two-fold) compared to basal levels in their respective control groups. Additionally, there is a noteworthy decrease in the protein expressions of TAS1R2, TAS1R3, and TRPM5 observed in both the duodenum and colon.[3] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | GPX | GlucagonReceptor | Glucagon Receptor | GLP Receptor | 3-Deoxyglucosone |
| Inhibitors Related | Tirzepatide Acetate(2023788-19-2 free base) | PF-06882961 | RSL3 | ML162 | (S, R)-LSN 3318839 | BCP-T.A | NNC 92-1687 | PKUMDL-LC-101-D04 | 6α-Methylprednisolone 21-hemisuccinate sodium salt | JKE-1674 | Orforglipron | LSN3318839 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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