3-Oxo-5β-cholanoic acid NEW
| Price | $41 | $63 | $91 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-21 |
Product Details
| Product Name: 3-Oxo-5β-cholanoic acid | CAS No.: 1553-56-6 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2025/05/21 |
Product Introduction
Bioactivity
| Name | 3-Oxo-5β-cholanoic acid |
| Description | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite that inhibits TH17 cell differentiation by directly binding to the transcription factor RORγt with a Kd of 1.13 μM. |
| In vitro | Treatment with 3-Oxo-5β-cholanoic acid significantly reduces the RORγt reporter's activity, likely by directly interacting with RORγt, thereby inhibiting TH17 cell differentiation by suppressing its transcriptional activity. |
| In vivo | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 65 mg/ml (173.54 mM), Sonication is recommended. |
| Keywords | transcription | TH17 | RORγt | ROR | responses | RAR-related orphan receptor | Inhibitor | inhibit | immune | factor | differentiation | cell | bile | acid | 3-oxoLCA | 3-Oxo-5β-cholanoic acid | 3Oxo5βcholanoic acid | 3-Oxo-5beta-cholanoic acid | 3-Oxo-5b-cholanoic acid | 3 Oxo 5β cholanoic acid |
| Inhibitors Related | S18-000003 | T0901317 | GSK2981278 | Nobiletin | XY101 | Cholesterol | AZD-0284 | Melatonin | SR2211 | Cabozantinib hydrochloride | RORγt Inverse agonist 6 | ML 209 |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Natural Product Library | Natural Product Library for HTS | Metabolism Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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