Product Details
| Product Name:
4-hydroxybutanal Basic information |
CAS No.:
25714-71-0 |
| Min. Order:
1kg |
Purity:
98% |
| Supply Ability:
1000kg |
Release date:
2025/11/25 |
| 4-hydroxybutanal Basic information |
| Product Name: | 4-hydroxybutanal |
| Synonyms: | 4-hydroxybutyraldehyde;4-Hydroxybutanal;Butanal, 4-hydroxy-;Einecs 247-205-3;gamma-Hydroxybutyraldehyde;4-Hydroxybutanal and 2-Hydroxytetrahydrofuran (Equilibrium Mixture);4-Hydroxybutanal and 2-Hydroxytetrahydrofuran |
| CAS: | 25714-71-0 |
| MF: | C4H8O2 |
| MW: | 88.11 |
| EINECS: | 247-205-3 |
| Product Categories: |
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| Mol File: | 25714-71-0.mol |
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| 4-hydroxybutanal Chemical Properties |
| Boiling point | 103.07°C (rough estimate) |
| density | 1.0808 |
| refractive index | 1.4384 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 14.89±0.10(Predicted) |
| color | Colourless |
| Stability: | Hygroscopic |
| EPA Substance Registry System | Butanal, 4-hydroxy- (25714-71-0) |
|
| 4-hydroxybutanal Usage And Synthesis |
| Uses | 4-Hydroxybutanal is used in preparation of deoxykeoses and acetonides. 4-Hydroxybutanal is also a metabolite of Tegafur , a prodrug used for various cancer chemotherapies. |
| Reactions | 4-Hydroxybutanal forms a cyclic hemiacetal when the hydroxyl oxygen add to the aldehyde group. Methanol reacts with this cyclic hemiacetal to form 2-methoxytetrahydrofuran which is our desired product.2-Methoxytetrahydrofuran is a cyclic acetal. The hydroxyl oxygen of 4-Hydroxybutanal reacts with the aldehyde to form cyclic ether linkage. |
| Synthesis | The 4-hydroxybutanal which is produced as the high yield product of the invention hydroformylation process can be separated and recovered by conventional distillation procedures. It is highly preferred, however, to subject the hydroformylation product mixture to aqueous phase extraction. Surprisingly it was found that water is capable of extracting 4-hydroxybutanal from the product mixture substantially to the exclusion of the other product mixture components. In a commercial scale operation, an aqueous phase stream can be contacted countercurrently and continuously with reaction product effluent from the hydroformylation reaction zone. The resultant aqueous phase containing 4-hydroxybutanal is an excellent vehicle for subsequent processing procedures, such as hydrogenation of 4-hydroxybutanal with Raney nickel to produce valuable 1,4-butanediol.
literature source US04064145 |
| References | [1] QINGYONG MENG Ming B H Chenggen Zhang. A theoretical model study on the cyclic reaction of 4-hydroxybutanal catalyzed by Br?nsted acid[J]. Canadian Journal of Chemistry, 2009, 68 1: 1610-1619. DOI:10.1139/V09-126.
[2] LUDMILA LEITE. Transformation of 4-hydroxybutanal over porcelain[J]. Journal of Molecular Catalysis A: Chemical, 1999, 144 2: Pages 323-328. DOI:10.1016/S1381-1169(98)00382-3.
[3] https://patents.google.com/patent/CN114149312A/en |
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| 4-hydroxybutanal Preparation Products And Raw materials |
| Raw materials | 1,2,4-Butanetriol-->Tetrahydrofuran-->1,4-Butanediol-->Allyl alcohol-->2,3-Dihydrofuran |
| Preparation Products | 4-Hydroxybutyric acid-->3-hydroxy-2-methyl propionaldehyde-->7-Ethyl tryptophol-->2-HYDROXYTETRAHYDROFURAN-->Gamma Butyrolactone-->1-Propanol |
Company Profile Introduction
Founded in 2014, Henan Aochuang Chemical Co., Ltd. is committed to the development of medical science and material chemistry technology. Based on the advanced technology for chemical and
medical , it specializes in the research, development, and sales of pharmaceutical intermediates, electronic intermediates ,battery material intermediates, and other fine chemicals. The company has professionals who have been engaged in chemical production and sales for many years. It is a vigorous pharmaceutical chemical technology enterprise with professional background.
90% of the company's products are sold to Japan, South Korea, Europe and the United States. We have maintained good cooperative relations with many international well-known enterprises, and have been well received by all parties. ?
Adhering to the principle of "quality first, customer first, integrity-based, mutual benefit", the company provides customers with high-quality products ranging from grams to tons, and comprehensive services from products to technology, and is willing to work together with all walks of life. , and jointly contribute to the development of the material and pharmaceutical industry!
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