4-Hydroxytamoxifen NEW
| Price | $64 | $89 | $197 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: 4-Hydroxytamoxifen | CAS No.: 68047-06-3 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | 4-Hydroxytamoxifen |
| Description | 4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer research. |
| In vitro | METHODS: The human endometrial adenocarcinoma cell line HEC-1B was treated with 4-Hydroxytamoxifen (0.01-100 µM) for 3 days, and cell viability was measured using the CellTiter 96 AQueous One Solution Cell Proliferation Assay. RESULTS: HEC-1B cells exposed to higher concentrations (1-100 µM) of 4-Hydroxytamoxifen showed significant differences in cell viability between concentrations. [1] METHODS: ER-positive breast cancer cell lines MCF-7, T47D and BT-474 were treated with 4-Hydroxytamoxifen (0.5-1 µM) and sulforaphane (5 µM) for 48 h. The expression levels of target proteins were detected using Western Blot. RESULTS: Sulforaphane induced PARP cleavage, the intensity of which was dependent on the cell line, and the combination of sulforaphane and 4-Hydroxytamoxifen further enhanced PARP cleavage. [2] |
| In vivo | METHODS: To detect the antitumor activity in vivo, 4-Hydroxytamoxifen (1 mg/kg) was injected intraperitoneally into Nu/Nu mice carrying human breast cancer tumor MCF-7 once a day for twenty-three days. RESULTS: 4-Hydroxytamoxifen effectively inhibited tumor growth in mice. [3] METHODS: To induce Cre recombinase activity, 4-Hydroxytamoxifen (30-60 mg/kg) was injected intraperitoneally into Rosa26BEST1-CreERT2 mice once daily for four days. RESULTS: TdTomato was strongly expressed in the RPE of mice of both sexes. [4] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 0.1 mg/mL (insoluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.16 mM), Sonication is recommended. DMSO : 58.3 mg/mL (150.45 mM), Sonication is recommended. |
| Keywords | progestogenReceptor | progestogen Receptor | nucleus translocation | ICI-79280 | ICI79280 | EstrogenReceptor | Estrogen Receptor/ERR | estrogen receptor | Estrogen Receptor | ERR | ER | 4-Hydroxytamoxifen | 4Hydroxytamoxifen | 4-hydroxy Tamoxifen | 4 Hydroxytamoxifen | (Z)-Afimoxifene |
| Inhibitors Related | Mifepristone | Estradiol | Astragaloside IV | Estradiol benzoate | Bisphenol B | Melatonin | Allura Red AC | Chrysin | 17α-Hydroxyprogesterone | Natamycin | Ethisterone | Cholesterol |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Anti-Ovarian Cancer Compound Library | Endocrinology-Hormone Compound Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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