4-Hydroxytolbutamide NEW
| Price | $142 | $555 | $987 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: 4-Hydroxytolbutamide | CAS No.: 5719-85-7 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | 4-Hydroxytolbutamide |
| Description | 4-Hydroxytolbutamide is a sulfonylurea and drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 Tolbutamide (HLS 831) is a sulfonylurea hypoglycemic agent. |
| In vitro | 4-Hydroxytolbutamide is the primary metabolite of tolbutamide, formed via CYP2C9 in humans and CYP2C11 in rats. In rat liver microsomes, the hydroxylation of tolbutamide follows typical Michaelis–Menten kinetics, indicating enzyme-mediated metabolism. [1] |
| In vivo | In poloxamer 407-induced hyperlipidemic rats, intravenous or oral administration of tolbutamide (10 mg/kg) produced significantly lower AUC values for 4-Hydroxytolbutamide compared to normal rats, indicating reduced metabolic conversion. [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (349.22 mM), Sonication is recommended. |
| Keywords | PotassiumChannel | Potassium channel | 4-Hydroxytolbutamide | 4Hydroxytolbutamide | 4 Hydroxytolbutamide |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Alginic acid | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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