4-Methoxyphenol NEW

**4-Methoxyphenol (4-MP)**, also known as **Mequinol** or **p-Hydroxyanisole**, is an organic compound with the chemical formula **C₇H₈O₂**. It is widely used in industrial, cosmetic, and medical applications due to its **antioxidant, depigmenting, and polymerization-inhibiting properties**. Below are its key applications:  

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### **1. Cosmetics & Skin Care (Primary Use)**  

#### **Skin Depigmenting Agent (Whitening/Bleaching)**  

- **Treatment of Hyperpigmentation**:  

  - Used in topical formulations (e.g., creams, serums) to lighten dark spots, **melasma**, **age spots**, and **post-inflammatory hyperpigmentation**.  

  - Often combined with **tretinoin** and **corticosteroids** (e.g., in the FDA-approved product **Solage®**).  

- **Mechanism**: Inhibits **tyrosinase**, the enzyme responsible for melanin production, thereby reducing skin pigmentation.  

#### **Antioxidant in Cosmetics**  

- Prevents oxidative degradation of skincare products by scavenging free radicals.  

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### **2. Industrial Applications**  

#### **Polymerization Inhibitor**  

- **Vinyl Monomers & Acrylates**: Added to **styrene**, **acrylic acid**, and other monomers to prevent unwanted **premature polymerization** during storage or transport.  

- **Adhesives & Resins**: Extends shelf life by inhibiting free-radical polymerization.  

#### **Rubber & Plastics Stabilizer**  

- Protects synthetic rubber and plastics from oxidative degradation.  

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### **3. Medical & Pharmaceutical Uses**  

- **Preservative**: Due to its antimicrobial properties, it is sometimes used in pharmaceuticals and vaccines.  

- **Research Applications**: Studied for potential **chemopreventive effects** in cancer due to its antioxidant activity.  

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### **4. Food & Agriculture**  

- **Antioxidant for Fats/Oils**: Occasionally used to prevent rancidity (though less common than BHA/BHT).  

- **Agricultural Chemicals**: Intermediate in the synthesis of certain pesticides and herbicides.  

Safety & Side Effects

Cosmetic Use: Generally safe at low concentrations (typically 2–5% in skin-lightening products), but may cause **skin irritation** or **allergic reactions** in sensitive individuals.  Industrial Handling: Can be toxic if ingested or inhaled in large quantities; requires proper protective equipment.  

Regulatory Status: Approved by the FDA for topical depigmentation but banned in some countries for over-the-counter skin bleaching due to misuse risks.