Chlormadinone acetate

Description :
(1) Chloromartanone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961, Used as an effective oral hormone for progesterone

Alternative therapy (HRT), and contraceptive with ethinyl estradiol (EE).

(2) Chloroformone acetate has a strong progestogen effect, about one third higher than progesterone, and can be based on the role of estrogen before the change, that estrogen can promote the formation of progesterone receptors and uterus Endometrial proliferation. Like progesterone, it is anti-estrogen and does not have some androgen effects (for contraceptive and HRT doses).

(3) contrary to progesterone, it has a slight role in glucocorticoids, and obvious anti-androgen effects, no salt corticosteroid effect. There is no evidence that CMA is not pregnant in humans.

(4) It is speculated that the anti-androgenic effect of CMA is the result of competitive inhibition of endogenous testosterone and dihydrotestosterone and competitive inhibition of 5-reductase in combination with androgen receptors. In this respect, the dose of CMA is critical; agonism is observed when the dose is increased from the optimal dose for antagonism.

(5) Glucoside acetate is a strong anti-gonadotropin effect through negative feedback on the secretion of gonadotropin. More than 20 years of contraceptive use has been used in only patients with arterial risk. The clinical and metabolic tolerances of CMA have been demonstrated in many clinical studies for a duration of up to 2.5 years.

(6) The latest application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven to be very successful, and the study reported excellent contraceptive efficacy, high tolerance and compliance, due to good side effects And the positive effects of pre-existing dysmenorrhea, skin and hair condition.

Applications

Chloramphenic acid hydrochloride is clinically used as a hormone contraceptive, in part because it reduces estrogen levels, and in order to improve the effectiveness of contraceptive methods, clomethanone is usually used in combination with ethinyl estradiol for this purpose. It is chloramphenicol acetate.

Chloromartanone acetate (CMA) is a naturally occurring progesterone derivative that exhibits high affinity and activity in progesterone receptors.

It has an antiestrogen effect, contrary to natural progesterone, with moderate antiandrogenic properties. CMA acts by blocking the androgen receptors in the target organ and by reducing the activity of the skin 5 -reductase.

It inhibits gonadotropin secretion, thereby reducing ovarian and adrenal androgen production. CMA inhibits ovulation due to inhibition or destruction of endogenous gonadotropin secretion, showing high contraceptive efficacy, thereby inhibiting follicular growth and maturation. In addition, it inhibits endometrial thickness and increases the viscosity of cervical mucus.