Regorafenib

Price	$5200
Package	1KG

Product Details

Product Name: Regorafenib	CAS No.: 755037-03-7
EC-No.: 1308068-626-2	Min. Order: 1G
Purity: 99%	Supply Ability: customise
Release date: 2019/07/06

WM0051 Article illustration

Regorafenib Basic information

Product Name:	Regorafenib
Synonyms:	Regorafenib;BAY 73-4506;4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;BAY 73-4506(Regorafenib);4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide;Regorafenib (BAY 73-4506);4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]-3-fluorophenoxy]-N-Methyl-2-pyridinecarboxaMide;4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide
CAS:	755037-03-7
MF:	C21H15ClF4N4O3
MW:	482.8154128
EINECS:	1308068-626-2
Product Categories:	Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Anti-cancer&immunity;Inhibitors
Mol File:	755037-03-7.mol

Regorafenib Chemical Properties

Melting point

206.0 to 210.0 °C

Safety Information

MSDS Information

Regorafenib Usage And Synthesis

Uses	It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Uses	BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.
Uses	Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively
Definition	ChEBI: A pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previ usly received chemotherapy, anti-EGFR or anti-VEGF therapy.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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Product Details

Company Profile Introduction

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career henan chemical co