A77 1726
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: A77 1726 | CAS No.: 163451-81-8 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| A77 1726 Basic information |
| Product Name: | A77 1726 |
| Synonyms: | A77 1726 (Teriflunomide);LeflunoMide EP IMpurity B;A 1726;Flucyamide;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide |
| CAS: | 163451-81-8 |
| MF: | C12H9F3N2O2 |
| MW: | 270.2072696 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Metabolites & Impurities;Tyrosine Kinase Inhibitors |
| Mol File: | 163451-81-8.mol |
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| A77 1726 Chemical Properties |
| Melting point | 229-232°C |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| color | white to beige |
| λmax | 203nm(MeOH)(lit.) |
| Merck | 14,9165 |
| InChIKey | UTNUDOFZCWSZMS-YFHOEESVSA-N |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| MSDS Information |
| A77 1726 Usage And Synthesis |
| Chemical Properties | White Solid |
| Uses | The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. |
| Definition | ChEBI: An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis. |
| Uses | A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical] |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
杨俊青
sales@coreychem.com
sales@coreychem.com