(±)5(6)-EET NEW
| Price | $497 |
| Package | 100μg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: (±)5(6)-EET | CAS No.: 87173-80-6 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | (±)5(6)-EET |
| Description | 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 μM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5(6)-EET is provided as a mixture of the free acid and lactone. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : >50 mg/mL (per Rao Maddipati), Sonication is recommended. Ethanol : >50 mg/mL (per Rao Maddipati), Sonication is recommended. DMF : >50 mg/mL (per Rao Maddipati), Sonication is recommended. PBS (pH 7.2) : >1 mg/mL (from 13(S)-HODE), Sonication is recommended. |
| Keywords | 5(6)-EET | (±)5(6)EET | (±)5(6) EET |
| Inhibitors Related | Quadrol | Tricaine methanesulfonate | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | Octopamine hydrochloride | Isoprenaline hydrochloride | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | D-Mannitol | Magnesium Chloride Hexahydrate | Magnesium sulfate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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TargetMol Chemicals Inc.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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