Product Details
| Product Name: DOTA | CAS No.: 60239-18-1 |
| Min. Order: 1KG | Purity: 98% |
| Supply Ability: 1000KGS | Release date: 2026/04/28 |
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DOTA Usage And Synthesis
Chemical Properties Colourless crystals
Uses 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.
It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
It can form complexes with gadolinium for application as MRI contrast agents.
Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.
Uses Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.
Definition ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.
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