ADU-S100 ammonium salt NEW
| Price | $433 | Get Latest Price |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-12 |
Product Details
| Product Name: ADU-S100 ammonium salt | CAS No.: 1638750-96-5 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2025/05/12 |
Product Introduction
Bioactivity
| Name | ADU-S100 ammonium salt |
| Description | ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity. |
| In vitro | METHODS: BMDCs were treated with free ADU-S100 (0.5 μg/mL) or liposomal ADU-S100 (0.1 μg/mL) for 24 hours, and IFNβ (A) and TNFα (B) levels in the cell culture medium were measured using ELISA. RESULTS ADU-S100 enhanced the production of TNFα and IFNβ in BMDCs. [1] METHODS: Mouse cDC2 and human cDC2 were cultured in 12.5-200 μM ADU-S100 for 24 hours, and the effects of ADU-S100 on cDC2 were observed. RESULTS 25 μM ADU-S100 increased the expression of Tim-3 on DC, showing a significant upregulation of Tim-3. [3] |
| In vivo | METHODS: After a 50 μg bolus injection of ADU-S100 on day 14 after intracranial implantation of GL261 mice, brain infiltrating leukocytes (BILs) were analyzed in detail by flow cytometry using a panel of 13 immune markers. RESULTS Three days after treatment of ADU-S100, suppression of microglia, CD4+ and CD8+ T cell populations, and infiltration of NK and CD11b/Gr1 inflammatory immune cells were observed, and 7 days after treatment, the proportion of T cells recovered and increased compared to baseline levels. CD45-negative cells decreased shortly after treatment. [2] METHODS: B16F1-OVA cells/100 μL PBS were injected into the right groin of C57BL/6 mice, and tumor-bearing mice were treated intratumorally with saline and 50 μg ADU-S100 every 2 days during the first week. Then, the dose of S100 was reduced to 30 μg, while the frequency of administration remained unchanged. RESULTS Mice treated with ADU-S100 lost weight and had smaller tumors. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 5 mg/mL (6.90 mM), Sonication is recommended. DMSO : 12 mg/mL (16.58 mM), Sonication and heating are recommended. |
| Keywords | TMEM173 | STING | Stimulator of Interferon Genes | MPYS | ML RR-S2 CDA ammonium | ML RR-S2 CDA | MIW815 ammonium | MIW-815 | MIW815 | MIW 815 | MITA | Inhibitor | inhibit | ERIS | ADUS100 ammonium salt | ADU-S100 ammonium | ADU-S100 | ADU S100 ammonium salt |
| Inhibitors Related | H-151 | SR-717 | ChX710 | SN-008 | Vadimezan | Dazostinag disodium | C-176 | Cridanimod | CCCP | diABZI STING agonist-1 trihydrochloride | MSA-2 | C-178 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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