Product Details
| Product Name:
AFMK |
CAS No.:
52450-38-1 |
| Purity:
98.34% |
Supply Ability:
10g |
| Release date:
2026/05/15 |
Product Introduction
Bioactivity
| Name | AFMK |
| Description | AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is a natural product and an apoptosis modulator with antioxidant and free radical scavenging activities. This compound enhances the antitumor effect of gemcitabine in PANC-1 cells and attenuates X-ray-induced oxidative damage to DNA, proteins, and lipids. |
| In vitro | Methods: Normal human epidermal keratinocytes were used as a model. AFMK was dissolved in ethanol and pre-incubated at concentrations of 10⁻³–10⁻⁹ M for 1 h, followed by 25 mJ/cm² UVB irradiation and 48 h culture. MTT, ATP, mitochondrial membrane potential, cytochrome c release, Caspase 3/7, and sub-G1 apoptosis assays were performed.
Results: AFMK significantly enhanced cell viability, maintained ATP and membrane potential, inhibited cytochrome c release, caspase activation, and apoptosis, exerting mitochondrial protective effects. [1]
Methods: Rat pancreatic acinar AR42J cells were used. Cells were incubated with 10⁻¹²–10⁻⁸ M AFMK combined with 10⁻⁸ M caerulein stimulation for 48 h. Western blot was used to detect GPx, TNF-α, Bcl-2, Bax, and Caspase-3 protein expression.
Results: AFMK dose-dependently increased GPx, Bax, and Caspase-3 levels, decreased TNF-α and Bcl-2 levels, and exerted protective effects by regulating antioxidant and apoptosis pathways.[2] |
| In vivo | Methods: In male Wistar rats, an acute pancreatitis model was induced by subcutaneous infusion of caerulein. AFMK (5, 10, 20 mg/kg) was administered by single intraperitoneal injection 30 min before modeling, with solvent being saline plus absolute ethanol; the control group received an equal volume of solvent.
Results: AFMK dose-dependently alleviated pancreatic tissue edema, reduced serum amylase and TNF-α levels, validating its in vivo anti-inflammatory and antioxidant activities.[3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (189.19 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.57 mM), Sonication is recommended.
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| Keywords | Human Endogenous Metabolite | Freeradicalscavengers | Free radical scavengers | EndogenousMetabolite | Endogenous Metabolite | Apoptosis | Antioxidant | AFMK |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Antioxidant Compound Library | Anti-Aging Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States