Product Details
| Product Name:
AFMK |
CAS No.:
52450-38-1 |
| Purity:
98.34% |
Supply Ability:
10g |
| Release date:
2025/11/08 |
Product Introduction
Bioactivity
| Name | AFMK |
| Description | AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells. |
| In vitro | In PANC-1 cell, AFMK in combination with Gemcitabine increases the inhibition of the production of HSP70 from 0.47 (Gemcitabine alone) to 0.13 (10 nM AFMK), 0.08 (0.1 nM AFMK) and 0.01 (0.001 nM AFMK)[1]. AFMK pretreatment significantly inhibits DNA damage and shows a very high hydroxyl radical scavenging potential with an IC50 of 338.08 nM[3]. |
| In vivo | In male C57BL mice, AFMK (10 mg/kg; i.p.) significantly reverses radiation-induced decline in the total antioxidant capacity of plasma. Pretreatment of AFMK shows a significantly lower value of comet tail length and % DNA in tail[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (189.19 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.57 mM), Sonication is recommended.
|
| Keywords | Human Endogenous Metabolite | Freeradicalscavengers | Free radical scavengers | EndogenousMetabolite | Endogenous Metabolite | Apoptosis | Antioxidant | AFMK |
| Inhibitors Related | Sucrose | Cysteamine hydrochloride | Daidzein | Fumaric acid | Guanidine hydrochloride | Tributyrin | Ferulic Acid | Glycerol | Thymidine | Naringin | Alginic acid | 3-Indoleacetic acid |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Antioxidant Compound Library | Anti-Aging Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States