Product Details
| Product Name:
AMG-548 |
CAS No.:
864249-60-5 |
| Purity:
99.91% |
Supply Ability:
10g |
| Release date:
2025/09/17 |
Product Introduction
Bioactivity
| Name | AMG-548 |
| Description | AMG-548 is a selective and orally active p38α MAPK inhibitor (Ki = 0.5 nM), with higher selectivity than p38β, p38γ, and p38δ, and can also inhibit the TNFα, CK1δ/ε, and Wnt signalling pathways. |
| In vitro | Methods: U2OS-EFC cells were treated with AMG-548 (0.01-0.1 μM) to investigate its ability to mediate Wnt-3a-induced hDvl2 mobility shift.
Results: AMG-548 inhibited hDvl2 displacement at micromolar concentrations. [2] |
| In vivo | Experimental data showed that AMG-548 exhibited differentiated pharmacokinetic characteristics in different animal models: the elimination half-life (t1/2) in rats was 4.6 hours, while in canine models it was extended to 7.3 hours. In terms of bioavailability (F value), the compound reached 62% in rats, while it was relatively low at 47% in dogs. These Results indicate that AMG-548 has significant species differences, and its metabolic clearance rate and absorption efficiency vary significantly between different animal models. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (173.33 mM), Sonication is recommended.
|
| Keywords | p38δ | p38γ | p38β | p38α | p38MAPK | p38 MAPK | JNK3 | JNK2 | JNK1 | dog p38α | CK1 | AMG-548 | AMG 548 |
| Inhibitors Related | Esculin | Urea | Acetylcysteine | Acefylline | Dodecane | Glucosamine | Apremilast | Lenalidomide | Fisetin | FERULIC ACID METHYL ESTER | Nisin Z | Methyl Vanillate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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