ARQ 069 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: ARQ 069 | CAS No.: 1314021-57-2 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | ARQ 069 |
| Description | ARQ 069 (3.8-60 μM; for 2 hours) reduces the degree of phosphorylation of FGFR (predominantly FGFR2) in a concentration-dependent manner, without decreasing β-actin. ARQ 069 shows an affinity for FGFR2 of 5.2 μM. ARQ 069 inhibits FGFR phosphorylation in Kato III cells (IC50: 9.7 μM). ARQ 069 targets the inactive forms of FGFR1 and FGFR2 kinases and inhibits their enzymatic activity. When ARQ 069 is preincubated with either phosphorylated FGFR1 or FGFR2, the potency of ARQ 069 in inhibiting Pyk2 phosphorylation is markedly reduced, with IC50 values determined to be greater than 30 and 24.8 μM for FGFR1 and FGFR2, respectively. ARQ 069 exhibits at least a 20-fold preference for binding to the unphosphorylated, inactive forms of FGFR1 and FGFR2. |
| In vitro | ARQ 069 (3.8-60 μM; for 2 hours) reduces the phosphorylation of FGFR, predominantly FGFR2, in a concentration-dependent manner without affecting β-actin[1]. It exhibits an affinity for FGFR2 at 5.2 μM[1] and inhibits FGFR phosphorylation in Kato III cells with an IC50 of 9.7 μM[1]. ARQ 069 targets the inactive forms of FGFR1 and FGFR2, inhibiting their enzymatic activity. Preincubation with phosphorylated FGFR1 or FGFR2 significantly reduces ARQ 069's potency in inhibiting Pyk2 phosphorylation, with IC50 values over 30 μM for FGFR1 and 24.8 μM for FGFR2. ARQ 069 shows a 20-fold preference for binding to unphosphorylated, inactive FGFR1 and FGFR2[1]. ARQ 068 is the R-enantiomer, while ARQ 069 is the S-enantiomer[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | unphosphorylated FGFR2 | unphosphorylated FGFR1 | FGFR2 autophosphorylation | FGFR1 autophosphorylation | ARQ-069 | ARQ069 | ARQ 069 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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