Azithromycin NEW
| Price | $56 | $84 | $219 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-31 |
Product Details
| Product Name: Azithromycin | CAS No.: 83905-01-5 |
| Purity: 99.97% | Supply Ability: 10g |
| Release date: 2025/10/31 |
Product Introduction
Bioactivity
| Name | Azithromycin |
| Description | Azithromycin (CP 62993) is a macrolide antibiotic that primarily targets the 50S subunit of bacterial ribosomes. Azithromycin is commonly used in studies of bacterial infections. |
| Cell Research | THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. |
| In vitro | METHODS: HeLa, MG-63 and Osteoblast cells were treated with Azithromycin (0-400 μg/mL) for 48 hours, and MTT assay was used to detect the inhibition of cell metabolic activity. RESULTS: Azithromycin inhibited the growth of HeLa (IC50=160 μM), MG-63 (IC50=180 μM) and Osteoblast (IC50=160 μM) cells. [1] |
| In vivo | METHODS: To study the effect of Azithromycin on asthma, a mouse model of asthma attack was treated with Azithromycin (50 mg/kg). RESULTS: Azithromycin had no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin did not induce general inflammatory parameters or LDH release in a mouse model of asthma exacerbations and increased expression of an interferon-stimulated gene and the pattern recognition receptor MDA5 but not RIG-I in mice with asthma exacerbations. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 18.33 mg/mL (24.47 mM), Sonication is recommended. Ethanol : 74.9 mg/mL (100 mM), Sonication is recommended. |
| Keywords | XZ450 | XZ 450 | protein synthesis | Inhibitor | inhibit | CP-62993 | CP62993 | Bacterial | Azithromycin | Autophagy | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Cysteamine hydrochloride | Adipic dihydrazide | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Metronidazole | 2-Amino-2-methyl-1-propanol | Fenpyroximate | Paeonol | BES |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Microbial Natural Product Library | FDA-Approved Drug Library | Natural Product Library for HTS | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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