Bay 65-1942 hydrochloride NEW
| Price | $119 | $197 | $652 |
| Package | 2mg | 5mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-28 |
Product Details
| Product Name: Bay 65-1942 hydrochloride | CAS No.: 600734-06-3 |
| Supply Ability: 10g | Release date: 2025/10/28 |
Product Introduction
Bioactivity
| Name | Bay 65-1942 hydrochloride |
| Description | Bay 65-1942 hydrochloride is an ATP-competitive and selective inhibitor of IKKβ. |
| In vitro | Administration of Bay 65-1942 before ischemia significantly reduces left ventricular infarct size compared to vehicle-treated animals, with observed reductions at all time points (prior to ischemia 42.7±4.1%, at reperfusion 42.7±7.5%, 2 hours of reperfusion 29.4±5.2%; each group P<0.05 vs. vehicle). Compared to sham animals, vehicle-treated animals show a significant increase in the infarct-to-area at risk (AAR) ratio (70.7±3.4 vs. 5.8±3.4%, P<0.05). Bay 65-1942 pretreatment (n=3) significantly lowers CK-MB levels compared to untreated animals prior to IR (14,170 ±3,219 units, P<0.05 vs. vehicle)[1]. |
| In vivo | AZD6244 and BAY 65-1942 demonstrate synergistic inhibition of cell viability at the dose combination (5 μM AZD6244+10 μM BAY 65-1942), which correlates with IC75 (CI?=?0.48±0.01). AZD6244 and BAY 65-1942 treatment induces 2- and 1.3-fold caspase 3/7 activation, respectively, compared to the DMSO-treated cells. Treatment with a combination of AZD6244 plus BAY 65-1942 leads to a 3.2-fold increase in caspase 3/7 activity[2]. Inhibitors of MEK (AZD6244) and IKK (BAY 65-1942) are used at their IC50 concentrations, as determined by a 48 hour MTS assay, which achieve sufficient inhibition of kinase activity. MYL-R cells are treated for 24 hours with AZD6244 (5 μM), BAY 65-1942 (10 μM), or a combination of these inhibitors at the same concentrations. Synergism is also indicated at the IC50 (CI?=?0.56±0.09) and IC90 (CI?=?0.46±0.02) dose combinations reported by the software (CI values are the mean of three independent experiments, ± standard deviation). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (115.76 mM), Sonication is recommended. |
| Keywords | IκB | IKKβ | IKK | IkB/IKK | IkB | Bay 65-1942 Hydrochloride | Bay 651942 hydrochloride | Bay 65 1942 hydrochloride |
| Inhibitors Related | JTP 0819958 - HOIPIN-1 | Amlexanox | Malachite green oxalate | Rosmarinic acid | BAY 11-7082 | SC-514 | Resveratrol | Bardoxolone Methyl | GSK8612 | BX795 | CCCP | Allicin |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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