BH3I-1 NEW
| Price | $54 | $89 | $168 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-22 |
Product Details
| Product Name: BH3I-1 | CAS No.: 300817-68-9 |
| Purity: 98.20% | Supply Ability: 10g |
| Release date: 2025/10/22 |
Product Introduction
Bioactivity
| Name | BH3I-1 |
| Description | BH3I-1 (BHI1) is a Bcl-2 antagonist. |
| Cell Research | Cells (5×104 cells per well) are seeded into white 96-well plates (Costar) and treated with various concentrations of the compounds for 48 h. For zVAD-FMK protection experiments, cells are preincubated with 100 μM zVAD-FMK for 1 h before the addition of chemicals. Cell viability is determined with an MTS assay. For PI staining experiments, cells are grown in 24-well plates and then incubated with 2 μg ml/L PI. Cell death is determined by FACS analysis.(Only for Reference) |
| In vitro | BH3I-1 inhibits Bcl-xL heterodimerization in vitro. It also induces cytochrome c release[1]. BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1a interactions[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 60 mg/mL (149.88 mM), Sonication is recommended. Ethanol : 11 mg/mL (27.48 mM), Sonication is recommended. |
| Keywords | Ubiquitin ligase | Ubiquitin conjugating enzyme | Ubiquitin activating enzyme | p53/MDM2 | MDM-2/p53 | Inhibitor | inhibit | E3Enzyme | E3 ligating enzyme | E3 Enzyme | E2Enzyme | E2 Enzyme | E2 conjugating enzyme | E1Enzyme | E1/E2/E3 Enzyme | E1 Enzyme | E1 activating enzyme | BHI-1 | BHI 1 | BH3I-1 | BH-3I-1 | BH3I1 | BH3I 1 | BH 3I1 | Bcl-xL-BH3 | Bcl-2 Family |
| Inhibitors Related | Cyanoacetamide | 10-Hydroxydecanoic Acid | Ascorbyl palmitate | Flubendazole | (S)-(+)-Ibuprofen | Amantadine | Hydralazine hydrochloride | Estradiol benzoate | Navitoclax | Venetoclax | Indole-3-carbinol | Thymoquinone |
| Related Compound Libraries | Cuproptosis Compound Library | Ferroptosis Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Glutamine Metabolism Compound Library | Anti-Parkinson's Disease Compound Library | Pyroptosis Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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