Product Details
| Product Name:
BI-3663 |
CAS No.:
2341740-84-7 |
| Supply Ability:
10g |
Release date:
2025/09/22 |
Product Introduction
Bioactivity
| Name | BI-3663 |
| Description | BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer. |
| In vitro | BI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC50s of 7.6 and 7.9, respectively[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 300 mg/mL (326.85 mM), Sonication is recommended.
|
| Keywords | PTK2/FAK:18 nM (IC50) | Cereblon | BI-3663 | BI3663 | BI 3663 |
| Inhibitors Related | ARV-393 HCl | Gefitinib-based PROTAC 3 | ACBI1 | ARV-471 | CCT367766 | dBET6 | Dbet57 | dBET1 | ARV-825 | AU-15330 | β-NF-JQ1 | C004019 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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