BIM-46174 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-29 |
Product Details
| Product Name: BIM-46174 | CAS No.: 195450-11-4 |
| Supply Ability: 10g | Release date: 2025/08/29 |
Product Introduction
Bioactivity
| Name | BIM-46174 |
| Description | BIM-46174 is a 5,6,7,8-tetrahydroimidazole [1,2-a] pyrazine derivative that inhibits the heterotrimeric Galpha/Gbetagamma protein complex and has anticancer activity, inhibiting the growth of a large number of human cancer cell lines, inducing caspase-3-dependent cancer cell apoptosis, and inducing poly (ADP-ribose) polymerase cleavage. |
| In vitro | METHODS: RAW-blue macrophages were pretreated with BIM-46174 (20 μM, 30 min) and then treated with 10 μg/mL imiquimod. Cell lysates from WT and KD cells were separated by SDS-PAGE, and the blots were probed with a phosphorylation-specific polyclonal rabbit antibody against NF-κBp65-Ser (P). RESULTS:BIM-46174 significantly blocked nucleic acid-induced TLR-7 and -9 MyD88 recruitment, NF-κB activation, and proinflammatory TNFα and MCP-1 cytokine responses. [3] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | BRD5814 | BRD 5814 | BIM-46174 | apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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| $133.00/1mg |
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2025-10-24 | |
| $812.00/100μg |
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TargetMol Chemicals Inc.
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2025-08-29 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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