Product Details
| Product Name:
BTX161 |
CAS No.:
2052301-24-1 |
| Supply Ability:
10g |
Release date:
2026/04/20 |
Product Introduction
Bioactivity
| Name | BTX161 |
| Description | BTX161 is a Thalidomide analogue. BTX161 is a potent CKIα degrader. In human AML cells, BTX161 mediates the CKIα degradation better than Lenalidomide as well as activates DNA damage response (DDR) and p53, and also stabilizes the p53 antagonist MDM2[1]. |
| In vitro | BTX161 (25 μM; 4 hours; MV4-11 cells) enhances the expression of Wnt targets such as MYC without altering MDM2 mRNA levels [1]. At a concentration of 10 μM over 6 hours in MV4-11 cells, BTX161 independently increases p53 and MDM2 protein levels. When combined with THZ1, and especially with both THZ1 and CDK9, it further elevates p53 expression and maximizes caspase 3 activation [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Hematein | TBCA | Ellagic acid | Casein | Casein Kinase II Inhibitor IV | Emodin | AS-252424 | LY-364947 | TA-01 | CK2/ERK8-IN-1 | Casein kinase 1δ-IN-14 | LY294002 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States