Product Details
| Product Name:
Butin |
CAS No.:
21913-99-5 |
| Purity:
99.91% |
Supply Ability:
10g |
| Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | Butin |
| Description | Butin, the major bioactive flavonoid isolated from Dalbergia odorifera heartwood, possesses oral activity with notable antioxidant, antiplatelet, and anti-inflammatory effects. This compound effectively alleviates myocardial infarction, improves cardiac function, and prevents diabetes-induced cardiac oxidative damage in rats. |
| In vitro | Methods: H9c2 cells were treated with Butin (12.5, 25, 50 μM, 6 hours). Cell viability was detected by MTT assay, target protein expression was detected by Western blotting, and target gene expression was detected by real-time qPCR.
Results: Butin increased cell survival in a dose-dependent manner, increased the expression of GSH-px, GSH, SOD, CAT, and HO-1, and increased the level of Nrf2 in the cytoplasm and nucleus in a dose-dependent manner, and enhanced the expression of GSH-px, GSH, SOD, CAT, and HO-1. [1] |
| In vivo | Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rats [1]. |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (293.85 mM), Sonication is recommended.
|
| Keywords | Butin |
| Inhibitors Related | Thiamine monochloride | Butylated hydroxytoluene | AFMK | L-Tartaric acid | Propyl gallate | Neohesperidin | Sulbutiamine | L-Cystine | 3-Indolepropionic acid | 4-hydroxyphenylacetic acid | 6-PPD | Trolox |
| Related Compound Libraries | Antioxidant Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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